| Pair Name | Morin, Fludarabine | ||
| Phytochemical Name | Morin (PubChem CID: 5281670 ) | ||
| Anticancer drug Name | Fludarabine (PubChem CID: 657237 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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| Pair Name | Morin, Fludarabine | |||
| Disease Info | [ICD-11: 2A82] | Chronic lymphocytic leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | ACP1 | hsa52 |
| Down-regulation | Expression | CXCL12 | hsa6387 | |
| Down-regulation | Expression | CXCR4 | hsa7852 | |
| Down-regulation | Expression | ITGB1 | hsa3688 | |
| In Vitro Model | MEC-1 | Chronic lymphocytic leukemia | Homo sapiens (Human) | CVCL_1870 |
| Result | Morin treatment in CLL-derived Mec-1 cell line synergizes with conventional anticancer drugs currently used in CLL therapy by affecting leukemic cell viability and trafficking. | |||
| No. | Title | Href |
|---|---|---|
| 1 | LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy. Cancer Cell Int. 2019 Mar 21;19:67. doi: 10.1186/s12935-019-0786-1. | Click |
